产品货号：
Z18799
中文名称：
Integrin Beta 4/ITGB4抗体
英文名称：
Anti-Integrin Beta 4/ITGB4 Antibody
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-Integrin Beta 4/ITGB4 Antibody |
| 指标别名 | CD104;GP150;Integrin beta 4;integrin;beta 4;ITGB4 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | IHC |
| 基因名称 | ITGB4 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin beta 4(45-62aa DKDCAYCTDEMFRDRRCN). |
| 成分 | 500μg/mL antibody with PBS，0.02% NaN3,1mg BSA and 50% glycerol. |
| 纯化方式 | Immunogen affinity purified. |
| 浓度 | 500μg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 12 months from date of receipt，-20℃ as supplied.6 months 2 to 8℃ after reconstitution.Avoid repeated freezing and thawing. |
| 背景资料 | ITGB4(Integrin,beta-4),also known as CD104(Cluster of Differentiation 104),is a human gene.The gene encodes the integrin beta 4 subunits,a receptor for the laminins.This subunit tends to associate with alpha 6 subunits and is likely to play a pivotal role in the biology of invasive carcinoma.The ITGB4 gene is mapped on 17q25.1.Using expression profiling,Yang et al.found that ITGB4 was upregulated 6-fold by ZKSCAN3 in transfected human colon cancer cells compared with parental cells.They confirmed that ZKSCAN3 bound the promoter of ITGB4 in vitro and in vivo.ITGB4 knockdown by short hairpin RNA countered ZKSCAN3-augmented anchorage-independent colony formation in the colon cancer cell lines.The integrin beta-4 subunit is characterized by an unusually long cytoplasmic domain that harbors 4 fibronectin type III(FNIII) repeats,residing in 2 pairs separated by a connecting segment.Vidal et al.found compound heterozygosity for mutations in the ITGB4 gene in an infant with junctional epidermolysis bullosa associated with pyloric atresia. |
| Uniprot ID | P16144 |
| 推荐配套试剂 | Biorab recommends Enhanced Chemiluminescent Kit with anti-Rabbit IgG (ZN1926) for Western blot,and HRP Conjugated anti-Rabbit IgG Super Vision Assay Kit (ZN1865) for IHC(P).*Blocking peptide可以联系我们购买。 |
| 基因名全称 | integrin,beta 4 |
| 蛋白名全称 | Integrin beta-4 |
| 推荐稀释比 | Immunohistochemistry in paraffin section IHC-(P) 1:50～400 (Boiling the paraffin sections in 10mM citrate buffer,pH6.0,or PH8.0 EDTA repair liquid for 20 mins is required for the staining of formalin/paraffin sections.) Optimal working dilutions must be determined by end user. |
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